Temporary swelling of the muscles results in stretching of the muscle fascia, which allows for continued muscle growth through a cascade of anabolic signals. The pump is also a powerful motivating factor, by acting as positive feedback on your workout and rewarding your efforts by making you look your best.
Thunderbolt by Antaeus Labs is an Advance Anabolic Vasodilator Utilizing the Following Ingredients
Kallidinogenase is a naturally-occurring vasodilatory human enzyme. The kallidinogenase, also known as kallikrein, found in Thunderbolt is a natural human enzyme in recombinant form. We use enteric coated acid-resistant capsules for maximum bioavailability and absorption from the GI tract.
Kallidinogenase increases peripheral and cerebral bloodflow via Bradykinin B1 and B2 receptors. It is a peripheral vasodilator. Kallidinogenase strongly increases prostaglandin levels, which may increase the anabolic response to exercise. It also has significant pro-fertility effects, is nephroprotective, has diuretic effects via activation of the Bradykinin B2 receptor, and increases bloodflow to the brain. B2 receptor activation also increases vascular permeability and allows the blood brain barrier to be crossed more easily.
Arginine Butyrate activates the nitric oxide pathway and inhibits histone deacetylase to increase follistatin and reduce myostatin.
HDAC inhibitors have potential as anabolic agents as they increase follistatin and reduce myostatin levels. In mouse models of muscular dystrophy arginine butyrate demonstrated beneficial effects including increased muscle strength and increased utrophin expression. Exposure of myoblasts to HDAC inhibitors results in upregulation of follistatin expression. In turn, follistatin binds to and suppresses the activity of myostatin, a TGF-β family member that negatively regulates muscle mass.
Arginine’s NO-mediated functions are fairly well known. L-arginine is converted into NO by the enzyme NO synthase (eNOS). Nitric oxide causes relaxation vascular smooth muscle by binding to and activating guanylate cyclase and increasing intracellular levels of cyclic-guanosine 3’,5’-monophosphate, causing vasodilation which lowers arterial pressure. This improves blood flow which increases the “pump”. Nitric oxide also inhibits platelet aggregation and adhesion. Arginine is also a precursor of creatine, and plays a role in accelerating tissue repair following injuries.
Copper is a trace element required for human health. It is included here to prevent diet-related deficiency, which may impair vasodilation. Copper deficiency has been shown to block acetylcholine-mediated vascular smooth muscle relaxation.
Copper potentiates the vasodilatory and antiplatelet actions of endogenous nitrosothiols: Copper ions are important catalysts in the decomposition of low molecular weight nitrosothiols (like GSNO) by superoxide dismutase (Cu/Zn SOD). . Copper also enables many metabolic functions, the absorption of iron and formation of red blood cells, and the function of the immune system.
Quercetin is a hydrophobic and lipophilic aglycone flavonol present in a wide variety of fruits and vegetables. Niacinamide is a form of Vitamin B3. As cocrystals the two compounds form a solid-state crystalline lattice structure, stabilized by hydrogen bonds.
Quercetin induces vasodilatory effects in humans in both in vivo and ex vivo experiments. Quercetin achieves this vasodilation by inducing phosphorylation of endothelial nitric oxide synthase (eNOS) in endothelial cells, and also by the production of endogenous vasodilatory prostanoids through cyclooxygenase enzyme inhibition. In vitro experiments suggest quercetin is capable of increasing blow flow in blood vessels by up to 50%. Quercetin-Niacinamide cocrystals have improved solubility and oral bioavailability profiles compared to free quercetin, with much faster time to maximum concentration (Tmax).
Quercetin has many potential beneficial effects, which have been studied to varying degrees of scientific rigour. Research has suggested anti-inflammatory properties (through the inhibition of histamine release from mast cells), inhibition of platelet aggregation, blood pressure-lowering effects (which may be dependent on an individual’s genetics), while evidence of improvements in human endurance has been equivocal.
Visnadine is a component of the plant Ammi visnaga (Bishop’s Weed), a member of the carrot family which has been used as a folk remedy around the Mediterranean since the time of the ancient Egyptians. Bishop’s Weed contains several compounds with vasodilatory properties including visnadine, visnagin, and khellin, of which visnadine is the most potent. It is used in Thunderbolt complexed with cyclodextrins, for improved bioavailability.
Visnadine is a peripheral and coronary vasodilator. It is believed to be vasodilatory through inhibition of calcium entry through voltage-gated L-type channels, and not through the release of endothelium-derived relaxing factors.